The history of Grandview Hospital goes back to 1926. In that year, the "Dayton Osteopathic Hospital" was founded by three physicians: William Gravett, DO; Heber Dill, DO; and Frank Dilatush, DO. The original hospital was located at 325 West Second Street in downtown Dayton.

The hospital adequately served the needs of the medical staff and their patients for several years. However, as the physicians' practices grew and more osteopathic physicians settled in Dayton, it became evident that a larger hospital was needed. Plans were soon made for a new building. Orville Wright donated $500 to the building fund. A site on Grand Avenue was purchased, and in 1947, a new 65-bed hospital was dedicated. At this time, the hospital was incorporated as a non-profit institution and renamed Grandview. In just two years, a wing was added to the new building, increasing the number of beds to 90.

Still, Grandview could not accommodate all the people seeking treatment. So, in 1950, a public campaign was initiated to raise funds for more beds. By the end of the campaign, $450,000 had been contributed by the medical staff, the public and private industry. The addition built from these funds raised the total number of beds to 165 and 21 bassinets.

More growth was seen in the late 1950s. This time a maternity wing was added onto the west side of the hospital, raising the bed total to 225 and 56 bassinets. Also included in this expansion were a new medical library, a large conference hall and additional office space, but even this expansion could not keep up with the high-occupancy needs. So in November of 1962, two new floors were opened, allowing for a total of 301 beds.

With the addition of beds over the years, the hospital's ancillary departments needed to expand as well. A $5.5 million project was completed in 1971 and 66 beds were added. Two years later, the Annex was connected to the main building, making Grandview a 411-bed hospital. A six-story addition was completed in the spring of 1984. Within this addition, the hospital houses three patient floors, three intensive care areas, a short-stay unit, state-of-the-art surgical suites and extensive ancillary service areas.